Five sepharose-bound ligands for the chromatographic purification of Clostridium collagenase and clostripain

Social media data have provoked a mixed response from researchers. While there is great enthusiasm for this new source of social data – Twitter data in particular – concerns are also expressed about their biases and unknown provenance and, consequently, their credibility for social research. This article seeks a middle path, arguing that we must develop better understanding of the construction and circulation of social media data to evaluate their appropriate uses and the claims that might be made from them. Building on sociotechnical approaches, we propose a high-level abstraction of the ‘pipeline’ through which social media data are constructed and circulated. In turn, we explore how this shapes the populations and samples that are present in social media data and the methods that generate data about them. We conclude with some broad principles for supporting methodologically informed social media research in the future

The motivation for citizens’ involvement in life sciences research is predicted by age and gender

Open Science is an umbrella term encompassing multiple concepts as open access to publications, open data, open education and citizen science that aim to make science more open and transparent. Citizen science, an important facet of Open Science, actively involves nonscientists in the research process, and can potentially be beneficial for multiple actors, such as scientists, citizens, policymakers and society in general. However, the reasons that motivate different segments of the public to participate in research are still understudied. Therefore, based on data gathered from a survey conducted in Czechia, Germany, Italy, Spain, Sweden, and the UK (N = 5,870), this study explores five types of incentives that can motivate individuals to become involved in life sciences research. The results demonstrate that men and younger individuals are more persuaded by extrinsic motives (external benefits or rewards), as compared with women and older people, who are driven by intrinsic motives (that originates from within an individual). This paper shows that specific strata of the population are differentially motivated to engage in research, thereby providing relevant knowledge for effectively designing public involvement activities that target various groups of the public in research projects

Mining Big Data for Tourist Hot Spots: Geographical Patterns of Online Footprints

Understanding the complex, and often unequal, spatiality of tourist demand in urban contexts requires other methodologies, among which the information base available online and in social networks has gained prominence. Innovation supported by Information and Communication Technologies in terms of data access and data exchange has emerged as a complementary supporting tool for the more traditional data collection techniques currently in use, particularly, in urban destinations where there is the need to more (near)real-time monitoring. The capacity to collect and analise massive amounts of data on individual and group behaviour is leading to new data-rich research approaches. This chapter addresses the potential for discovering geographical insights regarding tourists’ spatial patterns within a destination, based on the analysis of geotagged data available from two social networks. ·info:eu-repo/semantics/publishedVersio

Southampton PRegnancy Intervention for the Next Generation (SPRING):protocol for a randomised controlled trial

BACKGROUND: The nutritional status and health of mothers influence the growth and development of infants during pregnancy and postnatal life. Interventions that focus on improving the nutritional status and lifestyle of mothers have the potential to optimise the development of the fetus as well as improve the health of mothers themselves. Improving the diets of women of childbearing age is likely to require complex interventions that are delivered in a socially and culturally appropriate context. In this study we aim to test the efficacy of two interventions: behaviour change (Healthy Conversation Skills) and vitamin D supplementation, and to explore the efficacy of an intervention that combines both, in improving the diet quality and nutritional status of pregnant women. METHODS/DESIGN: Women attending the maternity hospital in Southampton are recruited at between 8 and 12 weeks gestation. They are randomised to one of four groups following a factorial design: Healthy Conversation Skills support plus vitamin D supplementation (1000 IU cholecalciferol) (n = 150); Healthy Conversation Skills support plus placebo (n = 150); usual care plus vitamin D supplementation (n = 150); usual care plus placebo (n = 150). Questionnaire data include parity, sunlight exposure, diet assessment allowing assessment of diet quality, cigarette and alcohol consumption, well-being, self-efficacy and food involvement. At 19 and 34 weeks maternal anthropometry is assessed and blood samples taken to measure 25(OH) vitamin D. Maternal diet quality and 25(OH) vitamin D are the primary outcomes. Secondary outcomes are women's level of self-efficacy at 34 weeks, pregnancy weight gain, women's self-efficacy and breastfeeding status at one month after birth and neonatal bone mineral content, assessed by DXA within the first 14 days after birth. DISCUSSION: This trial is evaluating two approaches to improving maternal diet: a behaviour change intervention and vitamin D supplementation. The factorial design of this trial has the advantage of enabling each intervention to be tested separately as well as allowing exploration of the synergistic effect of both interventions on women's diets and vitamin D levels. TRIAL REGISTRATION: ISRCTN07227232 . Registered on 13 September 2013

Engaging with charities on social media: comparing interaction on Facebook and Twitter

Social media are commonly assumed to provide fruitful online communities for organisations, whereby the brand and supporter-base engage in productive, two-way conversations. For charities, this provides a unique opportunity to reach an audience for a relatively low cost, yet some remain hesitant to fully embrace these services without knowing exactly what they will receive in return. This paper reports on a study that seeks to determine the extent to which these conversations occur, and compares this phenomenon on Facebook and Twitter for a sample of UK-based charities. Focus was placed on analysing conversations as signs of developing relationships, which have previously been shown to be a key target for charities on social media. The results of this study find that while there is an expected proportion of the audience who prefer to listen rather than engage, there is strong evidence of a core group of supporters on each site who repeatedly engage. Interestingly, disparities between how this occurs on Facebook and Twitter emerge, with the results suggesting that Facebook receives more conversations in response to the charities’ own posts, whereas on Twitter there is a larger observable element of unsolicited messages of people talking about the charity, which in turn produces a differing opportunity for the charity to extract value from the network. It is also found that posts containing pictures receive the highest number of responses on each site. These were a lot less common on Twitter and could therefore offer an avenue for charities to increase the frequency of responses they achieve